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What it is:

Dihydroberberine is a metabolite of berberine, a compound found in several plants. It’s a more bioavailable form of berberine, and thus can be more easily and effectively absorbed and utilized by the body. 


It is well-known for it’s ability in weight management – here’s why:

  1. AMPK Activation: dihydroberberine activates an enzyme called AMP-activated protein kinase (AMPK). AMPK plays a crucial role in regulating metabolism. When activate, AMPK promotes glucose uptake in cells, increases fatty acid oxidation, and reduces fat synthesis. This can lead to enhanced fat burning and reduced fat accumulation, particularly in abdominal fat. 
  2. Improved Insulin Sensitivity: By enhancing insulin sensitivity, dihydroberberine helps cells take up glucose more effectively. This reduces insulin levels in the blood thereby reducing cravings for carbohydrates and regulating appetite. 
  3. Reduced Inflammation: Chronic inflammation is often associated with obesity. Dihydroberberine has anti-inflammatory properties that may help reduce inflammation in adipose tissue (fat tissue), promoting healthier metabolism and potentially aiding in weight loss. 



This 2020 meta-analysis of 12 studies provides compelling evidence for the effectiveness of berberine in promoting weight loss and improving metabolic parameters. The findings show that berberine supplementation lead to significant reductions in body weight, BMI, and waist circumference. Additionally, berberine intake was associated with a reduction in C-reactive protein (CRP) levels, indicating an anti-inflammatory effect. The results reinforce berberine’s role as a beneficial supplement for weight management and metabolic health. This study from 2021 shows that supplementation with 200mg dihydroberberine lead to a substantially higher cumulative exposure of berberine in the bloodstream compared to 500mg berberine (929 土 694 ng/mL vs. 42.3 土 17.5 ng/mL, p=0.045), which is why 200mg dihydroberberine can be found in our fat burner.